17-AAG
17-AAG
17-AAG (pronounced seventeen-A-A-G), also known as Tanespimycin, is a derivative of the antibiotic Geldanamycin that is used for the treatment of cancer.
Etymology
The term 17-AAG is an abbreviation for 17-Allylamino-17-demethoxygeldanamycin. The name is derived from its chemical structure, which is a modification of the parent compound, Geldanamycin.
Usage
17-AAG is a Hsp90 inhibitor that has been studied in clinical trials for its potential use in the treatment of various types of cancer. It works by binding to Hsp90 and inhibiting its function, which disrupts the activity of several proteins that are involved in the growth and survival of cancer cells.
Related Terms
- Geldanamycin: The parent compound of 17-AAG.
- Hsp90: A protein that 17-AAG binds to in order to inhibit its function.
- Cancer: A group of diseases characterized by the uncontrolled growth and spread of abnormal cells, which 17-AAG is used to treat.
See Also
External links
- Medical encyclopedia article on 17-AAG
- Wikipedia's article - 17-AAG
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